“Protected PCI: Clinical Evidence and Best Practice Improvement” features presentations from Chuck Simonton, MD, Vasileios Panoulas, MD, and Christophe Vandenbriele, MD. Dr. Simonton provides an update on Impella® clinical trials: PROTECT III, RESTORE EF, and PROTECT IV RCT, as well mentioning the REVIVED BCIS2 study. Dr. Panoulas presents 3 case examples from his in daily clinical practice that illustrate LV improvement following Impella-supported PCI. Dr. Vandenbriele discusses managing anticoagulation in Impella-supported patients, highlighting the use of bicarbonate-based purge fluid for Impella.