In this CAMP at TCT exclusive case review, Jason Wollmuth, MD, FACC, and Amir Kaki, MD, FACC, FSCAI, discuss the importance of using a right heart catheter (RHC) to guide patient management decisions. Dr. Wollmuth presents two cases highlighting the importance of hemodynamics in guiding Impella® weaning in high-risk PCI. Dr. Kaki presents two cases of patients requiring right heart support—one in cardiogenic shock and one with pulmonary embolism—emphasizing the important role of RHC in guiding therapy.